C-terminal fragments of amyloid precursor protein have been blamed for endolysosomal dysfunction in Alzheimer’s disease. Now, scientists led by Wim Annaert at KU Leuven, Belgium, claim that’s because ...
Destructive Relief. In the proposed strain relief mechanism, left-twisted tau fibrils bind D-peptides, which initially adopt ...
No Ride for Lysosomes. In wild-type i3 neurons (left), LAMP1+ lysosomes (white) are found in dendrites, soma, and axons. Without BORC5 (middle) or BORC7 (right), few lysosomes travel into axons.
Numerous studies have cast TREM2-expressing microglia as good guys in the Alzheimer’s brain, but new research suggests some play a darker role. In the April 18 Nature Neuroscience, researchers led by ...
A new study adds to the evidence that a class of diabetes drugs could help Parkinson’s patients, even if only a little. In the April 4 New England Journal of Medicine, researchers led by Olivier ...
Microglia seem to play a hand in every aspect of Alzheimer’s pathogenesis, from the seeding and clearing of plaques to the traveling of tau to the dying of neurons. Scientists are pursuing ...
Among plasma biomarkers for Alzheimer’s disease, p-Tau217 stands tall as having the highest diagnostic accuracy. Now, in the March 23 Nature Communications, researchers led by Przemyslaw Kac, Thomas ...
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