Iran’s supreme leader has dismissed any discussion of whether Tehran’s unprecedented drone-and-missile attack on Israel hit anything there.

Two U.S. officials tell CBS News an Israeli missile has hit Iran in apparent retaliation for the recent drone and missile attack​ on the Jewish state.

The retaliatory attack damaged a defense system near Natanz, a city in central Iran that is critical to the country’s nuclear weapons program.

Iran could review its "nuclear doctrine" following Israeli threats, a senior Iranian Revolutionary Guards commander said on Thursday, raising concerns about Tehran's nuclear programme which it has always said was strictly for peaceful purposes.

On Friday, explosions were heard over the Iranian city of Isfahan in what sources said was an Israeli attack but Tehran played down the incident and said it had no plans for retaliation. Iran launched a barrage of missiles and drones at Israel on April 13 in what it said was retaliation for Israel's suspected deadly strike on its embassy compound in Damascus on April 1,

While Israel has maintained its official silence, the alleged use of the Rampage missile—a 1,250-pound air-to-ground precision strike weapon with GPS/INS guidance navigation—points to a significant escalation in the shadow conflict between the two nations.