A violent, tornado-spawning storm system tore across the central US, leaving at least 25 people dead in Missouri and southeastern Kentucky as it cut a path of destruction through several states.

A wave of severe weather has resulted in tragedy as multiple tornadoes swept across the central and eastern United States, claiming at least 28 lives, injuring dozens more, and leaving as many as a half-million without power.

Severe storms that tore through the US states of Missouri, Kentucky and Virginia left more than 25 people dead, leveling homes and businesses while knocking out power for tens of thousands, authorities say.