Some new medications in development are also trying to solve for a persistent side effect of existing drugs: Patients who lose fat also tend to lose muscle. This can be particularly dangerous for older adults because it makes them more likely to fall and can worsen osteoporosis.

A new generation of weight-loss drugs has proven remarkably effective, hugely popular and massively lucrative in the last few years, though they do have some drawbacks.

Tufts University scientists are aiming to revolutionize the future of weight loss drugs by engineering a new compound that targets four gut hormones instead of the usual one to three. These next-gen tetra-functional peptides may overcome the limitations of current drugs like Ozempic and Mounjaro especially their nausea,

Patients on GLP-1 medications lost about half as much weight as participants did in clinical trials, NYU researchers found.

Options are emerging for the tens of millions of people who stop taking GLP-1 drugs because of side effects, cost or availability.

Former FDA chief Dr. David Kessler says the new weight-loss drugs are a powerful tool to fight obesity. But they come with pitfalls. Here's his tips for how to use them successfully.

Overweight patients given an experimental weight loss drug being developed by China's Sciwind Biosciences lost an average of 10% to 15% of their body weight, roughly in line with results from a similar drug sold by Novo Nordisk ,

Novo Nordisk A/S’s latest experimental obesity drug helped patients lose as much as 24.3% of their weight in a small study, showing its potential as a next-generation treatment in the hyper-competitive market.

Novo Nordisk on Friday said full results from early-stage trials show that its experimental drug, amycretin, helped overweight and obese adults lose up to 24% of their weight as the Danish company readies for late-stage studies to start next year.